What is Carmustine

Carmustine is used to treat diseases like myeloma in which cells of our bone marrow that are conscientious for the production of antibodies become cancerous. It acts like a chemotherapy agent. In addition, it is fundamentally used to treat Hodgkin’s diseases, non-Hodgkin’s lymphomas and brain tumors.

This chemotherapy drug works by snooping with cell growth and it acts like an alkylation agent, which anchors an alkyl chemical group to the DNA of cells to prevent cell growth. Its consequence is on all cells but mostly it is seen on the cells which are harmful for our body like cancer cells which has a power of replicating.

This drug can be administered intravenously or it can be placed inside the cavity produced by a brain tumor extraction. When this agent is administered intravenously then it has side-effects like feeling of nausea with vomiting and it will continue for a few hours after the drug is administered. To reduce this or prevent this antiemetic are given before the treatment.

If carmustine is given in the form of doses, then its overdose can cause scarring in the lungs. There can be even signs of damage in the liver such as elevated transaminase, alkaline phosphates’, and billirubin. If continuous or equal amount of dose is not given then kidney problems occur. Because there is increase in urea, creatinine and nitrogen containing substances in the blood.

If carmustine drug is administered intravenously then it can cause severe blood toxicity. It will restrict the production of red and white blood cells and platelet.

There can also be hematologic effects with its use and if there is any adverse effect seen on our body then its dosage is adjusted during the weekly blood test.

All these side-effects are due to administration of carmustine intravenously but if this drug is placed inside a tumor cavity then its side-effects are comparatively less. But seizures, brain edema and speech and movement problems are still there.

The following precautions must be taken:-

Avoid alcohol. Do not aspirin, pain medicines, blood thinners, garlic, ginkgo or vitamin E. Use birth control that you can trust to prevent pregnancy while taking this drug.

Avoid being near people who have cold, flu or other contagious illness.

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